NMN vs NR: Perbedaan utama
Sebuah studi otoritatif baru hadir! Sebuah eksperimen tahun 2025 oleh tim Northwest A&F University, yang dipublikasikan di Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), mengungkapkan dengan data yang ketata the true health effects of NMN and NR—two NAD+ precursors that both support gut health, fight inflammation and oxidation, yet each has its own distinct strengths. After reading this, you’ll never have to struggle over which to choose again!
BAGIAN 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Menyeimbangkan Mikrobiota Usus: Bakteri Lebih Bermanfaat, Lebih Stabil
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Gambar 1: Efek pemberian makan NMN dan NR terhadap keragaman mikroba usus pada tikus.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Gambar 2: Efek pemberian makan NMN dan NR terhadap keragaman mikroba usus pada tikus.
C: Kelimpahan spesies tingkat filum dalam kelompok yang diberi makan NMN;
D: Kelimpahan spesies tingkat filum dalam kelompok NR-fed
Anti-inflamasi dan Antioksidan Double Boost: Melindungi Kesehatan dari Metabolisme hingga Gen
Peradangan dan kerusakan oksidatif adalah penyebab utama dari banyak gangguan. NMN dan NR menghadapinya dari kedua sisi:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Gambar 3: Peta panas metabolit diferensial pada kelompok NMN
Gambar 4: Peta panas metabolit diferensial pada kelompok NR-fed
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Gambar 5: Efek pemberian makan NMN dan NR terhadap faktor inflamasi usus pada tikus.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: Ekspresi PCR interleukin 6 (IL-6);
BAGIAN 02
Perbedaan Utama: Memilih NMN atau NR untuk Optimasi Kesehatan yang Presisi
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Gambar 6: Statistik sel goblet di usus besar tikus
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
BAGIAN 03
Choose According to Your Needs—Science Over Guesswork
Temuan tahun 2025 memperjelas: NMN dan NR bukanlah pengganti, melainkan opsi pelengkap. Apakah tujuan Anda melindungi kesehatan usus atau meningkatkan vitalitas fisik, memilih prekursor NAD+ yang tepat yang didukung oleh literatur otoritatif memberikan kesehatan Anda lapisan ganda kepastian.
BAGIAN 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Sejak 2012, Bontac Bio telah menjadi perusahaan teknologi tinggi yang mengkhususkan diri dalam teknologi biokatalisis. Dalam mengembangkan dan memproduksi NR Malate (NRHM), perusahaan mengintegrasikan keahlian dan inovasi uniknya, menampilkan keunggulan teknis dan produk yang luar biasa.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Kepatuhan dan Sertifikasi: Bontac memegang sertifikasi internasional FSSC 22000, Self-GRAS, FDA, Kosher, dan HALAL, memastikan kepatuhan penuh terhadap standar global mulai dari R&D hingga produksi. Studi tambahan, termasuk anti-fotoaging dan tes tingkat NAD+ ikan zebrafish, semakin memverifikasi efektivitas dan potensinya.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
BAGIAN 01
The Common Power: NMN and NR Both Build the Body’s Foundation
The study divided 45 C57 mice into three groups: one control group drinking plain water, and two groups gavaged with NMN or NR (400 mg/(kg·d), 5 times per week). After 8 weeks, the results were astonishing: both compounds achieved consensus in regulating gut health and metabolism.
Menyeimbangkan Mikrobiota Usus: Bakteri Lebih Bermanfaat, Lebih Stabil
The gut microbiota functions like a “miniature ecosystem”—the richer and more balanced it is, the healthier the host. The experiment found that after NMN or NR supplementation, the “richness” (Chao1 index) and “diversity” (Shannon index) of gut microbiota in mice increased significantly, meaning more beneficial bacteria and fewer harmful ones.
Gambar 1: Efek pemberian makan NMN dan NR terhadap keragaman mikroba usus pada tikus.
A: Comparison of intestinal microbial α-diversity between the control and NMN groups;
B: Comparison of intestinal microbial α-diversity between the control and NR groups.
The dominant bacterial phyla also shifted: Bacteroidota (responsible for nutrient absorption and immune regulation) and Pseudomonadota increased, while Actinomycetota (associated with inflammation when imbalanced) decreased, without causing dysbiosis—essentially adding a “stabilizer” to the gut.
Gambar 2: Efek pemberian makan NMN dan NR terhadap keragaman mikroba usus pada tikus.
C: Kelimpahan spesies tingkat filum dalam kelompok yang diberi makan NMN;
D: Kelimpahan spesies tingkat filum dalam kelompok NR-fed
Anti-inflamasi dan Antioksidan Double Boost: Melindungi Kesehatan dari Metabolisme hingga Gen
Peradangan dan kerusakan oksidatif adalah penyebab utama dari banyak gangguan. NMN dan NR menghadapinya dari kedua sisi:
Metabolically: both significantly upregulated anti-inflammatory fatty acid metabolites such as oleic acid and linoleic acid, as well as antioxidant metabolites like salicylic acid—adding a “natural defense shield” to the body.
Gambar 3: Peta panas metabolit diferensial pada kelompok NMN
Gambar 4: Peta panas metabolit diferensial pada kelompok NR-fed
Genetically: quantitative PCR testing confirmed that both compounds inhibited the expression of pro-inflammatory factors such as TNF-α and IL-6, effectively reducing inflammation at its source.
Gambar 5: Efek pemberian makan NMN dan NR terhadap faktor inflamasi usus pada tikus.
A: PCR expression of tumor necrosis factor-α (TNF-α);
B: Ekspresi PCR interleukin 6 (IL-6);
BAGIAN 02
Perbedaan Utama: Memilih NMN atau NR untuk Optimasi Kesehatan yang Presisi
While they share core benefits, the study clearly identified each compound’s area of expertise. Choose according to your needs for double the results.
NMN: The “Guardian” of Gut Barrier Health
If you often experience gut discomfort or worry about mucosal damage, NMN is the better choice. It significantly increases the number of goblet cells in the colon—these “mucus factories” secrete protective mucus that forms a physical barrier between harmful bacteria and intestinal epithelium, enhancing gut resistance. NMN also more strongly modulates gut microbiota diversity and strengthens local immunity through the “Bacteroidota–fatty acid” axis—essentially a personalized gut health solution.
Gambar 6: Statistik sel goblet di usus besar tikus
Figure 7: Comparison of intestinal microbial α-diversity among mice in the control, NMN, and NR groups
NR: The “Booster” for Muscle Vitality
Want to improve muscle strength and reduce fatigue? NR shines here! Surprisingly, mice in the NR group showed significantly higher grip strength than those in the NMN and control groups. Mechanistically, NR upregulates metabolites like arachidic acid (for membrane repair) and L-asparagine (for energy optimization), activates core energy pathways such as the TCA cycle, and downregulates oxidative stress markers like hydroquinone—essentially “energizing and unburdening” muscles for peak performance.
Figure 8: Statistics of mice’s grasping ability
BAGIAN 03
Choose According to Your Needs—Science Over Guesswork
Temuan tahun 2025 memperjelas: NMN dan NR bukanlah pengganti, melainkan opsi pelengkap. Apakah tujuan Anda melindungi kesehatan usus atau meningkatkan vitalitas fisik, memilih prekursor NAD+ yang tepat yang didukung oleh literatur otoritatif memberikan kesehatan Anda lapisan ganda kepastian.
BAGIAN 04
Bontac Bio’s NR Malate: Excellence in NR Technology and Quality
Sejak 2012, Bontac Bio telah menjadi perusahaan teknologi tinggi yang mengkhususkan diri dalam teknologi biokatalisis. Dalam mengembangkan dan memproduksi NR Malate (NRHM), perusahaan mengintegrasikan keahlian dan inovasi uniknya, menampilkan keunggulan teknis dan produk yang luar biasa.
Exclusive Technological Edge: Bontac Bio’s NR Malate holds the world’s first crystal form patent, achieving a molecular-level breakthrough that optimizes product performance. As a pioneer in the NMN industry, Bontac applies its globally original all-enzyme catalytic process—an innovation leading the industry. To date, the company has filed over 200 domestic and international invention patents and established China’s first provincial Coenzyme Engineering Technology Research Center, building strong competitive advantages through solid R&D strength.
Uncompromising Product Quality: Bontac enforces rigorous quality control standards. Third-party testing by CTI confirmed that NR Malate contains no detectable cadmium, mercury, lead, or arsenic—ensuring safety from the source. High-performance liquid chromatography revealed almost no impurity peaks, while moisture and microbial indicators far exceeded industry standards, reflecting exceptional purity. Critically, stability testing showed that under normal light-protected conditions, Bontac NR Malate degraded at only half the rate of regular NR (NRCL), ensuring reliable quality in both long-term storage and product applications.
Kepatuhan dan Sertifikasi: Bontac memegang sertifikasi internasional FSSC 22000, Self-GRAS, FDA, Kosher, dan HALAL, memastikan kepatuhan penuh terhadap standar global mulai dari R&D hingga produksi. Studi tambahan, termasuk anti-fotoaging dan tes tingkat NAD+ ikan zebrafish, semakin memverifikasi efektivitas dan potensinya.
Today, Bontac NR Malate is steadily advancing in compliant applications. For more insights into NR technology or premium product development, follow Bontac Bio—an industry leader in coenzyme biotechnology dedicated to sharing its R&D stories and quality standards.
